The main effects of Exemestane ZPHC

Exemestane is an irreversible steroidal aromatase inhibitor, similar in structure to the natural substance androstenedione. Exemestane does not have progestogenic and estrogenic activity. Only slight androgenic activity is detected, mainly at high doses. Exemestane does not affect the biosynthesis of cortisol and aldosterone in the adrenal glands, which confirms the selectivity of the drug. In this regard, there is no need for replacement therapy with glucocorticoids and mineralocorticoids. When using the drug, even at low doses, there is a slight increase in the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the blood serum, which is typical for drugs of this pharmacological group and probably develops according to the feedback principle at the pituitary gland level: a decrease in estrogen concentration stimulates the secretion of gonadotropins in the pituitary gland also in postmenopausal women.

ZPHC Exemestane Solo Course Rules

The recommended dose is 25 mg once daily, preferably after meals.In patients with early breast cancer, it is recommended to continue treatment with the drug until the total duration of consecutive adjuvant hormone therapy reaches 5 years. Treatment of patients with advanced breast cancer is long-term. If signs of progression of the tumor disease appear or if contralateral breast cancer appears, treatment with Exemestane should be discontinued. Liver or kidney failure

What side effects should athletes be wary of?

In general, Aromasin is well tolerated; Undesirable effects when using the drug at a dose of 25 mg / day are mostly minor or moderately pronounced. Adverse reactions are listed below, distributed by system organ class and frequency: very often (≥1 / 10), often (≥ 1/100, but < 1/10), infrequently (≥ 1/1000, but < 1/100) , rare (≥ 1/10,000 but < 1/1000). Metabolic and eating disorders: often – anorexia. From the gastrointestinal tract: very often – abdominal pain, nausea; often – vomiting, diarrhea, constipation, dyspepsia, increased appetite; infrequently – stomach ulcer.

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